Chapter 5 Evaluation of selected South African plant ,

respectively Lower EC50 values in the antioxidant and antiplatelet studies indicate superior activity of the plant extract against oxidation and platelet aggregation Keywords: South African plants, antioxidant assay, antiplatelet activity, cytotoxicity effect...

Plant Alkaloids as Antiplatelet Agent: Drugs of the Future ,

Sep 22, 2016· Antiplatelet mechanism of plant alkaloids Various mechanisms have been proposed for the antiplatelet activity of different isolated plant-alkaloids (Figure (Figure1) 1)Researchers have proposed that berberine significantly inhibited platelet aggregation by inhibiting synthesis of thromboxane A2 induced by adenine diphosphate, arachidonic acid, collagen (Chu et al, 1996)...

In vitro antiplatelet activity-guided fractionation of ,

Apr 26, 2005· To determine the in vitro antiplatelet aggregation property, 100 μl of the various fractions of the plant, in different concentrations (100 μg/ ml, 200 μg/ml, 400 μg/ml, 500 μg/ml), respectively was added to the platelet suspension at different concentrations for 1 min exposure at 37° before treatment with platelet aggregating agents ....

An Overview of Medicinal Plants as Potential Anti-Platelet ,

An Overview of Medicinal Plants as Potential Anti-Platelet Agents Mridul Bhowal1, Darshika M Mehta2 1B Pharm, PES College of Pharmacy, 50 feet road, Hanumanthanagar, , Chang FR, Wei JL, Teng CM, and Wu YC, Antiplatelet aggregation constituents from Annona purpurea, J ,...

Frontiers | Plant Alkaloids as Antiplatelet Agent: Drugs ,

The commonly used antiplatelet, aspirin, originated from salicin obtained from willow plant commonly used in pain medication This review describes various alkaloids isolated from plant sources having antiplatelet activity with possible mechanisms and candidates for further detailed studies in the drug discovery as antiplatelet agents...

Antithrombotic activity of flavonoids and polyphenols rich ,

Antiplatelet activity of flavonoids was revisited a decade later, as methodology of plate- , THE EFFECT OF FLAVONOIDS AND PLANT EXTRACTS ON PLATELET AGGREGATION ADP is a weak agonist of platelet aggregation, and is secreted from platelets upon activation by any other inducer of aggregation Thus, even a weak inhibitor of platelet...

Evaluation of selected South African plant species for ,

Evaluation of selected South African plant species for antioxidant, antiplatelet, and cytotoxic activity M M Suleiman1,2, V Bagla1, , was used to determine the inhibitory effect of the plant extracts on platelet aggregation Briefly, fresh equine (Equus caballus) ....

Antiplatelet Aggregation Coumarins from the Leaves of ,

antiplatelet aggregation induced by arachidonic acid (AA) and collagen [4] In the continuing phytochemical investigation, two coumarins, minumicroline acetonide (1) [5-6] and epimurpaniculol senecioate (2), were isolated from the methanoic extracts of the leaves of this plant by the way of bioactivity-guided fractionation method...

Antiplatelet activity of white and pink Nelumbo nucifera ,

Antiplatelet activity of white and pink Nelumbo nucifera Gaertn flowers 581 CaCl2 at a final concentration of 2μM Platelet aggregation was recorded by increasing transmittance value of spec-trophotometric measurements To determine the in vitro antiplatelet aggregation property, different concentrations...

Natural supplements, herbs, vitamins and food: Do some ,

Natural supplements, herbs, vitamins and food: Do some prevent blood clots? By Beth Waldron, MA and Stephan Moll, MD Patients who have ended their recommended course of prescription anticoagulation treatment are understandably concerned about a clot recurrence and will ask is there anything I can do to prevent a future clot?...

Antiplatelet aggregation activity of diterpene alkaloids ,

Aug 02, 2002· japonica var incisa, was found to selectively inhibit rabbit platelet aggregation induced by arachidonic acid in vitro and ex vivo and that the inhibition was much stronger than that of aspirin (Shen et al, 2000) In the present study, the antiplatelet aggregation activities of some natural atisine-type alkaloids isolated from S...

Inhibitory Effect of Lantana camara L, Eclipta prostrata ,

If the rupture is very large, then most likely there will be a blockage in the large blood vessels 1 The formation of such thrombus is medically preventable with antiplatelet aggregation agents Some of medicinal plants from Indonesia have hemostasis-related activities eg Lantana camara L, Eclipta prostrata (L) L) dan Cosmos caudatus Kunth)...

Bioactive peptides and proteins as alternative ,

Proteins and peptides derived from snake venoms and plants represent exciting candidates for the development of novel and potent antiplatelet agents Consequently, this review discusses multiple peptides that have displayed antiplatelet aggregation activity in preclinical drug development stag...

In vitro antiplatelet activity-guided fractionation of ,

Apr 26, 2005· To determine the in vitro antiplatelet aggregation property, 100 μl of the various fractions of the plant, in different concentrations (100 μg/ ml, 200 μg/ml, 400 μg/ml, 500 μg/ml), respectively was added to the platelet suspension at different concentrations for 1 min exposure at 37° before treatment with platelet aggregating agents ....

Alkaloids from Houttuynia cordata and Their Antiplatelet ,

Alkaloids from Houttuynia cordata and Their Antiplatelet Aggregation Activiti , 103724/SPJ1009201100425 Chinese Journal of Natural Medicines Alkaloids from Houttuynia cordata and Their Antiplatelet Aggregation Activities QU Wei 1 , WU Fei-Hua 2 , LI Juan 2 , LIANG Jing-Yu 1* 1 Department of Natural Medicinal Chemistry, China ....

Evaluation of selected South African plant species for ,

Evaluation of selected South African plant species for antioxidant, antiplatelet, and cytotoxic activity M M Suleiman1,2, V Bagla1, , was used to determine the inhibitory effect of the plant extracts on platelet aggregation Briefly, fresh equine (Equus caballus) ....

Bioactive peptides and proteins as alternative ,

Proteins and peptides derived from snake venoms and plants represent exciting candidates for the development of novel and potent antiplatelet agents Consequently, this review discusses multiple peptides that have displayed antiplatelet aggregation activity in preclinical drug development stag...

List of Platelet aggregation inhibitors - Drugs

Platelet aggregation inhibitors work in different places of the clotting cascade and prevent platelet adhesion, therefore no clot formation Aspirin, the most commonly used antiplatelet drug changes the balance between prostacyclin (which inhibits platelet aggregation) and thromboxane (that promotes aggregation)...

ANTIPLATELET AYURVEDIC HERBS IN THE MANAGEMENT ,

ANTIPLATELET AYURVEDIC HERBS IN THE MANAGEMENT OF CARDI-OVASCULAR DISEASE-A REVIEW Vidhya Unnikrishnan1, Nishteswar K 2 1 PhD scholar, 2 Professor& Head, Department of Dravyaguna, IPGT&RA, GAU, Jamnagar, Gujarat, India INTRODUCTION Cardiovascular disease (C VD), in-cluding heart disease and stroke, is the...

In Vitro Antiplatelet Aggregation Activity of Centella ,

antiplatelet aggregation activity Keywords: antiplatelet aggregation, Centella asiatica, n-hexane purification INTRODUCTION Platelet aggregation has many benefits for organism such as on homeostasis, xenobiotic phagocytoses, interaction with virus, bacteria or antigen-antibody complex However, it also has dangerous effects...

Herbal or Natural Supplements with Antiplatelet Properties ,

The use of herbal or natural medicines is increasing among patients and many of these products share pharmacologic properties with medications that require a prescription1 It is also well known that oral antiplatelet medications (such as aspirin, clopidogrel, prasugrel, ticlopidine, dipyridamole/aspirin) for the prevention and/or treatment of ....

Frontiers | A Novel Antiplatelet Aggregation Target of ,

Jun 14, 2019· And the platelet aggregation-related genes were discovered in databases, and antiplatelet aggregation-related gene targets were selected through comparison The functions of target genes and related pathways were analyzed and screened using the DAVID database, and the network was constructed using Cytoscape software...

Goniothalamus tapis - Wikipedia

Goniothalamus tapis is a species of plant in the family AnnonaceaeIt is native to Peninsular Malaysia, Sumatra, and Thailand Bioactive molecules extracted from its bark and roots have been reported to inhibit platelet-activating factor receptor binding in tests with rabbit platelets Description It is a tree reaching 15 to 40 feet in height...

Comparative study of Antiplatelet Aggregation Activity of ,

Plant extracts having an antiplatelet aggregation activity may be a potential choice for development of anti-inflammatory drugs because of their natural origin The extraction of bioactive compounds being the most crucial step in the commercial development of natural products it is essential to have rapid and efficient phytochemical...

(PDF) Antiplatelet aggregation and cytotoxic activity of ,

Jun 10, 2015· Antiplatelet aggregation and cytotoxic activity of betulinic acid and its acetyl derivative from Melaleuca bracteata Article (PDF Available) in Journal of medicinal plant research 9(22):647-654 ....

(PDF) Effect of Isoquinoline Alkaloids of Different ,

Effect of Isoquinoline Alkaloids of Different Structural Types on Antiplatelet Aggregation in Vitro Yi-Chen Chia1, Fang-Rong Chang2, Chin-Chung Wu2, Che-Ming Teng3, Keh-Shaw Chen1, Yang-Chang Wu2 Abstract Forty-one isoquinoline alkaloids were tested for antiplatelet ag- gregation effects...

ANTIPLATELET AYURVEDIC HERBS IN THE MANAGEMENT ,

ANTIPLATELET AYURVEDIC HERBS IN THE MANAGEMENT OF CARDI-OVASCULAR DISEASE-A REVIEW Vidhya Unnikrishnan1, Nishteswar K 2 1 PhD scholar, 2 Professor& Head, Department of Dravyaguna, IPGT&RA, GAU, Jamnagar, Gujarat, India INTRODUCTION Cardiovascular disease (C VD), in-cluding heart disease and stroke, is the...

(PDF) Effect of Isoquinoline Alkaloids of Different ,

Effect of Isoquinoline Alkaloids of Different Structural Types on Antiplatelet Aggregation in Vitro Yi-Chen Chia1, Fang-Rong Chang2, Chin-Chung Wu2, Che-Ming Teng3, Keh-Shaw Chen1, Yang-Chang Wu2 Abstract Forty-one isoquinoline alkaloids were tested for antiplatelet ag- gregation effects...

In vivo assessment of anticoagulant and antiplatelet ,

Background Syzygium cumini (L) Skeels is one of the very popular traditionally used medicinal plants with numerous pharmacological activities including antioxidant, hypoglycemic and anti-inflammatory However, actions of S cumini on blood coagulation and other parameters of blood were poorly pharmacologically studied Therefore, aim of this present investigation is to examine the effects ....

ANTIPLATELET ACTIVITY OF HYDROALCOHOLIC ,

platelet aggregation, a biological activity that could provide the products derived from this part of the plant with an antithrombotic potential This work was aimed to assess the possible antiplatelet activity of SOP...